Gregory Anthony Isaacs (born 15 July 1950) is a Jamaican reggae musician.
Isaacs was born in Fletchers Land, Kingston, Jamaica. In the 1970s, he emerged as one of the most prolific and popular recording artists in Jamaica. He released a number of self-produced singles on his African Museum (JA) record label, formed in 1973 with Errol Dunkley. Much of Isaacs' output reflected the 'conscious' themes of roots reggae, but Isaacs was equally adept at interpreting more mainstream lovers rock material. His hits include "My Only Lover", "Sinner Man" and "Mr. Cop", recorded at Lee Perry's Black Ark Studio.